Today at Berkeley Lab

Berkeley Lab Signs CRADA with City of Nanjing

As part of the Cooperative Research & Development Agreement with the Nanjing High-Tech Zone (NHZ), the Lab’s Gary Karpen, Mina Bissell, Bo Hang, Jian-Hua Mao, and Weiguo Zhang will help discover targets for mitigation or cure to promote product development in cancer-related fields. They met with the Nanjing mayor (pictured with Bissell) last month.

Time-Lapse Analysis Offers New Look at How Cells Repair DNA Damage

A computerized way has been developed to measure DNA repair in thousands of human mammary epithelial cells before and after they’re exposed to ionizing radiation. Microscopy images are acquired about every half hour over a span of up to two days, and the resulting sequence of images shows hotspots inside cells where DNA is under repair. More>

An Emerging Challenge to Science’s Credibility

A key feature of science is the ability to reproduce experiments, checking another group’s work by using its materials and following its methods then comparing the results. But worries have grown that many nonreproducible results are working their way into the scientific literature. Berkeley Lab life scientist Mina Bissell is quoted in the article. More>

Eva Nogales Awarded Mildred Cohn Award in Biological Chemistry

The award honors the pioneering scientific accomplishments and spirit of the late Professor Cohn — the first female president of the American Society for Biochemistry and Molecular Biology — and recognizes scientists that have made substantial advances in understanding biological chemistry using innovative physical approaches. More>

Molecular Imaging Innovation Delivers Spatial, Spectral Info Simultaneously

Using physical chemistry methods to look at biology at the nanoscale, Ke Xu of Life Sciences has invented a new technology to image single molecules with unprecedented spectral and spatial resolution, enabling new ways to examine cell structures and study diseases like Alzheimer’s. More>

An Atomic View of Microtubules

Life scientist Eva Nogales led a study in which microtubules — hollow fibers of tubulin protein that form the cytoskeletons of living cells and play a crucial role in mitosis — were imaged at a record resolution of 3.5 Angstroms. The images enabled them to identify how a family of end-binding proteins helps regulate microtubule dynamic instability. More>

Susan Celniker Creates STEM Fund in Her Father’s Memory

When Life Sciences Division Science Deputy Sue Celniker’s father passed away recently, she felt that there could be no more fitting tribute to his dedication to science and engineering and his firm support of women in STEM than to set up a fund in his name: the Leo Celniker Fund for Women in Science. More>

A Better Way to Screen Chemicals for Cancer-Causing Effect

Paul Yaswen is developing a cell culture that better identifies chemicals that increase breast cancer susceptibility. His team will grow the culture using adult stem cells obtained from breast tissue. Unlike today’s cell cultures, their test will show if a chemical causes a breakdown in cell-to-cell communication…a fundamental defect of cancer. More>

Making the Portable Gamma Camera

The end of the Cold War and the cancellation of the Superconducting Super Collider led to the creation of this life-saving medical device. Berkeley Lab’s Steve Holland and William Moses were an integral part of that development. More>

Lab Scientist Named Pew Scholar in Biomedical Sciences

The Pew Charitable Trusts recently named Ke Xu of the Life Sciences Division one of 22 Pew scholars in the biomedical sciences, an honor that is given to promising early-career researchers. Xu’s research uses sophisticated microscopy and single-molecule techniques to probe how a cell’s cytoskeleton organizes its interior and determines its shape. More>