Today at Berkeley Lab

Unwinding a Quadruple Helix to Help Develop Cancer-Fighting Drugs

Certain DNA sequences can fold into quadruple helix structures called G-quadruplexes. These sequences are present in nearly 40 percent of all human genes and in many oncogenes (genes with cancer-causing potential). With the help of the Advanced Light Source, researchers visualized the unfolding of a G-quadruplex by a protein called DHX36, gaining valuable insight into a possible target for drug development. More>