Today at Berkeley Lab

Un-Junking Junk DNA

A recent study shines a new light on molecular tools our cells use to govern regulated gene expression. Researchers uncovered a novel mechanism that allows proteins that direct pre-mRNA splicing – RNA-binding proteins – to induce a regulatory effect from greater distances than was thought possible. The discovery expands potential targets of rationally designed therapies which could correct molecular defects through antisense RNA oligonucleotides – small pieces of DNA or RNA that can bind to specific RNA targets to either block interactions with RNA-binding proteins and/or initiate degradation of the target RNA. Study co-authors include Sherry Gee, Marilyn Parra, Dana Ghanem, and Henry Marr of the Life Sciences Division. More>