Today at Berkeley Lab

New Insight into an Emerging Genome-Editing Tool

Jennifer Doudna of the Physical Biosciences Division and Eva Nogales of the Life Sciences Division led a study that provided the first detailed structural look at the Cas9 enzyme and how it partners with guide RNA to interact with target DNA. High-resolution protein crystallography images from the Advanced Light Source and the Swiss Light Source provided the 3D structure of this bacterial enzyme that has become an important tool for genome editing. Single-particle analysis using electron microscopy revealed a surprise role for guide RNA in the genome editing process. More>

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