Protein ‘Traffic Jams’ Linked to Malignant Activity in Breast Cancer

July 2, 2013

Jay Groves of the Physical Biosciences Division led a study in which it was demonstrated that the malignant activity of a critical cellular protein system strongly linked to breast cancer, the EphA2/ephrin-A1 complex, can arise from what essentially are protein traffic jams. Using an artificial membrane embedded with gold nanodots, Groves and his team showed that transport of this complex is normal in healthier cell lines but becomes jammed in diseased cell lines, with the worst jamming taking place in the cells that are the most diseased. On this team with Groves were Theobald Lohmuller and Qian Xu. More>

Tags: ,

Views: 942

Leave a Reply