The Road to a Nobel Prize Led Through the ALS

October 12, 2012

In 2003, Robert Lefkowitz and his colleagues collected data on the kinase of a cell-membrane protein called the G protein-coupled receptor (GPCR), using the newly commissioned Howard Hughes Medical Institute’s x-ray crystallography beamlines at the Advanced Light Source. Last Wednesday, Lefkowitz and Brian Kobilka, among the first to piece together the structure of GPCRs, learned they had been awarded the 2012 Nobel Prize in Chemistry for elucidating their function. GPCRs, which mediate cellular signal detection, have been the intense target of drug design efforts for many years; nearly half of all pharmaceutical drugs function by regulating these proteins. More>

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